WebJun 18, 2024 · The phosphatase and tensin homolog ( PTEN) hamartoma tumor syndrome (PHTS) is a grouping of related genetic disorders that has been linked to germline … http://www.phosphatome.net/wiki/index.php/Phosphatase_Subfamily_Tensin
Phosphatase and Tensin Homolog in Non-neoplastic Digestive …
WebAug 28, 2024 · Summary PTENP1 represents a highly homologous processed pseudogene of PTEN (phosphatase and tensin homolog), a protein that encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. PTENP1 is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: … WebPhosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor gene located at chromosome 10q23.31, encoding for a 403-amino acid protein that possesses both lipid and protein phosphatase activities. The main function of PTEN is to block the PI3K pathway by dephosphorylating phosphatidylinositol (PI) 3,4,5 … iob neft form word format
PTENP1 phosphatase and tensin homolog pseudogene 1 [ (human)]
Webphosphatase and tensin homolog, b-catenin, p53, endometrial carcinoma. C ancer of the uterine corpus is the most common gynecologic malignancy in the U.S., with … Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: … See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by sarcopoterium. See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more WebSep 24, 2024 · Furthermore, MSC-Exo loaded with phosphatase and tensin homolog small interfering RNA (ExoPTEN) could attenuate the expression of PTEN in the injured spinal cord region following intranasal administrations. In addition, the loaded MSC-Exo considerably enhanced axonal growth and neovascularization, while reducing microgliosis and … iob neft challan