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WebAbout this book. Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC ... WebOUR COMPANY. We are a clinical stage biopharmaceutical company specializing in novel therapeutics to treat chronic, high-prevalence ophthalmic diseases WebJan 1, 2013 · The Cys-linked ADC described here utilizes the linker maleimidocaproyl-valine-citrulline-para-aminobenzyloxycarbonyl (MC-VC-PABC) to attach the hydrophobic cytotoxic drug monomethyl auristatin E (MMAE) to a monoclonal antibody (Fig. 1) [].To make the ADC, the antibody is partially reduced to convert the interchain disulfides to free cysteine … signs of a hiatal hernia in women