Shank3 phosphorylation
Webb16 aug. 2024 · Shank3 is essential for synaptic scaling up, as previously demonstrated by Turrigiano and her colleagues (Tatavarty et al., Neuron, 2024). In their recent study, they … WebbGlycogen synthase kinase 3 (GSK3)-β (GSK3β) interaction protein (GSKIP) is one of the smallest A-kinase anchoring proteins that possesses a binding site for GSK3β.
Shank3 phosphorylation
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Webb28 okt. 2024 · To investigate whether δ-catenin phosphorylation via TNIK affects the binding to Shank3, we coexpressed the WT or a kinase dead TNIK constructs with Shank3 and δ-catenin. In addition, we also mutated one of the phosphorylation sites (T1064) to alanine or to glutamate. WebbShank1 and Shank3 contain several RSK consensus phosphorylation sites (RXRXXS, where X is any amino acid) and both Shanks were efficiently phosphorylated by RSK2 in vitro (data not shown). Indeed, RSK2 phosphorylated Shank1 (368–932) with a K m value (0.17 μM) far below that for the S6 peptide (9.6 μM), a standard RSK2 in vitro substrate, …
Webb18 okt. 2024 · SHANK3 deficiency results in the upregulation of Cdc2like kinase 2 (CLK2) expression, then lead to the phosphorylation and activation of serine/threonine protein … WebbThe SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD) (1), where they play a critical role in PSD assembly of excitatory synapses during development (2).
Webb7 apr. 2024 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12 ... Webb26 mars 2024 · Shank3, a master postsynaptic scaffolding protein that controls the developmental maturation of excitatory synapses, was recently shown … Protein-protein …
Webb26 mars 2024 · The synaptic scaffolding protein Shank3 binds CaMKII, ABI1, and many other proteins. We show that Ser685 in Shank3 can be phosphorylated by CaMKII or …
Webb7 okt. 2011 · Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic … how it works narcotics anonymous pdfWebb功能: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. how it works - resume now resume-now.comWebb25 maj 2024 · Since SHANK3 is a large essential scaffolding protein in the PSD, we sought to investigate phosphorylation-mediated SHANK3 regulation. To establish the SHANK3 … howit works pregnancy testsWebb29 apr. 2024 · Using a parallel proteomic analysis performed on Shank3 isolated from rat neocortical neurons by immunoaffinity, we identified two sites that were hypo-phosphorylated during scaling up and hyper-phosphorylated during scaling down: one (rat S1615) that corresponded to S1539 in mouse, and a second highly conserved site, rat … how it works refrigeratorWebbSummary Shank3 is an important scaffolding protein in the postsynaptic density (PSD). It functions in forming multiple complexes that anchor receptors, but also in connecting … how it works narcotics anonymous readingWebbHere, we discover that Shank3 is a specific binding partner for autoinhibited CaMKIIα. We demonstrate that Shank3 and GluN2B, via combined actions of Ca2+and phosphatases, reciprocally bind to CaMKIIα. Under basal condition, CaMKIIα is recruited to the Shank3 subcompartment of postsynaptic density (PSD) via phase separation. how it works na printableWebb26 apr. 2024 · Shank3 is a multidomain scaffold protein highly enriched at the postsynaptic density ( Naisbitt et al., 1999) and interacts with a number of other scaffold and … how it works:real time pcr