Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand … See more The first described candidate Siglec was Sialoadhesin (Siglec-1/CD169) a lectin-like adhesion protein on macrophages. Parallel studies by Ajit Varki and colleagues on the previously cloned CD22 (a B cell surface protein involved in See more The primary function of Siglecs is to bind glycans containing sialic acids. These receptor-glycan interactions can be used in cell adhesion, cell … See more Many pathologies have been linked to the spontaneous interactions between sialic acid and the immunosuppressive sialic acid-binding … See more Siglecs are Type I transmembrane proteins where the NH3 -terminus is in the extracellular space and the COO -terminus is See more This table briefly summarises the cellular distribution of each human/primate Siglec; the linkage specificity each has for sialic acid binding; the number of C2-Ig domains it contains; and … See more • Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group • I-type Lectins (Siglecs) Research conducted at Imperial College London providing another overview of I-type Lectins See more WebJan 24, 2024 · Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its …
SIGLEC1 Gene - GeneCards SN Protein SN Antibody
WebSiglec-8 is a glycan-binding protein member of the ligand sialic acid-binding, immunoglobulin-like lectin family. It is highly expressed on human eosinophils but also … WebMar 16, 2024 · Background: Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members are involved in regulating immune-cell activation, proliferation, and apoptosis, … phill stone whyalla
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WebSep 1, 2024 · Based on sequence homologies of human Siglecs, members of the Siglec family can be subdivided in two groups: one group comprises CD33 (Siglec-3)-related … WebJul 13, 2005 · Our group therefore suggested the name—“Siglec,” which contains elements of “ S ialic acid,” “ i mmuno g lobulin,” and “ lec tin.”. Following discussions with the … WebIt is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. phill station