WebAug 8, 2024 · Klotho, found in the cerebrospinal fluid, plasma, and membranes, is involved in maintaining calcium homeostasis (kidneys) and controlling insulin and insulin-like growth … WebThe Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Tissue specificity. Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid.
The role of Klotho and FGF23 in cardiovascular outcomes of …
Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. When the subfamily is not specified, the word "klotho" typically refers to the α-klotho subfamily, because α-klotho was discovered before the other members. WebThe klotho gene was identified as an "aging-suppressor" gene in mice that accelerates aging when disrupted and extends life span when overexpressed. It encodes a single-pass transmembrane protein and is expressed primarily in renal tubules. The extracellular domain of Klotho protein is secreted into blood and urine by ectodomain shedding. dynabreeze 400mm ip65 smart outdoor wall fan
Klotho: Alpha-Klotho and Beta-Klotho - peptidesciences.com
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